The literature was searched using the terms “STING”, “STING and periodontitis”, “TBK1”, “TBK 1 and periodontitis”, “IRF3”, “IRF3 and periodontitis”, “cGAS”, and “cGAS and periodontitis” by S.E. and M.Y., using the databases of PubMed/Medline, Scopus, and Web of Science. The gene discussed is CGAS; the disease is periodontitis.