Variables independently associated with the occurrence of very early (<6 months) distant recurrence in multivariate logistic regression analysis were bifocal vs. unifocal (OR = 5.16, p < 0.001), trifocal vs. unifocal HCC (OR = 7.18, p = 0.002), AFP > 100 ng/mL (OR = 16.6, p < 0.001) and HCC-naïve patient (OR = 0.26, p = 0.001). Here, AFP is linked to hepatocellular carcinoma.