Even though tumor characteristics (size, multifocality, serum α-fetoprotein (AFP) level) were shown as strong predictors of recurrence and survival [5,6,9,10,11,12] in this HCC population, little is known in Western series where the number of HCC nodules has only been studied as a binary variable (uni- vs. multifocal) [6,7,9,12]. The gene discussed is AFP; the disease is hepatocellular carcinoma.