In line with this data, in osteosarcoma tissues and cell lines, TRIB2 is a direct target of miR-509-5p and when miR-509-5p is overexpressed or TRIB2 is silenced, the malignant capacity of osteosarcoma cells, in terms of proliferation and invasion, its reduced [103]. Here, TRIB2 is linked to osteosarcoma.