Patients in EMPEROR-Reduced, as compared to DAPA-HF, had a lower left ventricle ejection fraction (27% vs. 31%), higher baseline NT-proBNP values (~1900 vs. 1430 pg/mL) and worse renal function (~61 vs. ~66 mL/min/1.73 m2). This evidence concerns the gene NPPB and hydrops fetalis.