NFKB2 and neoplasm: Resting cells exposed to healthy matrix showed A20 gene downregulation concomitant with NFKB2 growing expression after 12 h of culture (h3D vs. 2D p = 0.001), while in the tumor condition at the same time point it was observed an NFKB1 increase (t3D vs. h3D p = 0.043) in contrast to a marked NFKB2 decrease (t3D vs. h3D p < 0.001).