Further research is needed to clarify the impact of ACE2 activator, DIZE, on proinflammatory macrophages, especially nowadays, as ACE2 is recognized as both binding receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and important factor limiting lung injury in coronavirus disease-19 (COVID-19) caused by SARS-CoV-2. The gene discussed is ACE2; the disease is COVID-19.