Furthermore, other beta-3 glycosyltransferase upregulated in CRC cells known as C1GALT1 (core 1 β1,3-galactosyltransferase) promotes cell invasion, stem-like cell phenotype and radioresistance via modifying the O-glycosylation pattern of FGFR2 (fibroblast growth factor receptor 2) and β1 integrin, respectively (Table 1) [26,37]. Here, C1GALT1 is linked to colorectal carcinoma.