It has been shown that BGJ398, an OGT inhibitor, can significantly inhibit the activity of core 1 O-Glycan T-Synthase (C1GALT1) that catalyzes the transfer of Gal from UDP-Gal to GalNAc-alpha-1-Ser/Thr of cell surface proteins, such as the fibroblast growth factor receptor 2 (FGFR2), resulting in a significant decrease in the invasive capacity of CRC cells (Figure 1). The gene discussed is OGT; the disease is colorectal carcinoma.