CD274 and colorectal carcinoma: STT3 downregulation decreases the stability and the immunosuppressive activity of programmed death receptor 1 (PD-L1) through the inhibition of PD-L1 glycosylation and consequently increases the population of CD8+ T cells and the expression of granzyme B. Therefore, the inhibition of PD-L1 glycosylation reduces the immune evasion through blocking Wnt/β-catenin/STT3 signaling pathway in CRC cells (Figure 1) [106].