In addition, a dense and diverse O-glycosylation pattern of mucins, such as MUC2 described as the main gel-forming mucin, is a key protective factor against colitis and CRC through the supply of health nourishment for the gut microbiota, maintenance of mucus bacterial adhesion capacity and protection from digestive proteases [19,86]. This evidence concerns the gene MUC2 and colorectal carcinoma.