IDH1 and glioblastoma: The distinction of “IDH wild-type/WNT upregulated” and “IDH mutant/WNT downregulated” glioblastomas is major as these differences are not only biologically distinct subtypes but also associated with different clinical presentations, such as age and survival rate, with significantly shorter overall survival observed in patients with “IDH wild-type/WNT upregulated” glioblastoma [28].