First, EGFR activation causes the glycolytic enzyme pyruvate kinase isozymes M2 (PKM2) to translocate to the nucleus, where it phosphorylates histone 3 at Thr11, causing dissociation of histone deacetylase 3 (HDAC3), and promotes histone acetylation to regulate transcription of the cancer-promoting genes, including c-Myc and cyclin D1 [60]. The gene discussed is HDAC3; the disease is cancer.