Moreover, as mentioned above, in human astrocytomas, a decrease of THRα1 and/or THRα2, and increase of THRβ1 have been observed, thus suggesting that, at least in the case of these brain cancers, alterations in the combination of the expressed nuclear receptors might also have an importance [277,279]. The gene discussed is THRB; the disease is astrocytoma (excluding glioblastoma).