CHRNA3 and hepatocellular carcinoma: In addition, DNA hypermethylation was observed in HCC tumors at specific genes such as Ras Association Domain Family Member 1 (RASSF1A), Glutathione S-transferases (GSTP1), Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3), and Docking protein 1 (DOK1) compared to normal or cirrhotic tissues [63].