On the other hand, DMNT1 expression is also increased by vIRF1 inhibition of p53 transcriptional activity, thus leading to increased expression of high mobility group box 2 (HMGB2) and cytidine/uridine monophosphate kinase 1 (CMPK1) genes, which are involved in cell motility and proliferation, and their upregulation is associated with poor prognosis in KS and other tumors. This evidence concerns the gene HMGB2 and Kaposi's sarcoma.