Additionally, Wijetunga et al. demonstrated that HCV-infected liver tissues are hyper-methylated at active enhancer regions enriched for the binding of transcription factors Forkhead Box Protein A1 (FOXA1), Forkhead Box Protein A1 (FOXA2), and Hepatocyte Nuclear Factors 4 alpha (HNF4A) and that correlated with reduced expression of genes involved in liver cancer as stem cell phenotype development [64]. This evidence concerns the gene HNF4A and liver cancer.