In fact, AKT can inactivate EZH2 by phosphorylation of serine 21 and therefore EZH2 overexpression does not increase PRC2 activity but rather favors the formation of the polycomb repressive complex 4 (PRC4) [194,195,196] which is involved in cancer and inflammation [197,198,199]. The gene discussed is EZH2; the disease is cancer.