Recently, Zhang et al. reported that miR-22-3p derived from ADSC-Exos attenuates apoptosis and brain ischemia by inhibiting the lysine demethylase 6B (KDM6B)-mediated bone morphogenic protein 2 (BMP2)/Bcl-2 modifying factor (BMF) axis in rats after I/R injury [119]. The gene discussed is KDM6B; the disease is brain ischemia.