Several genetic variants located in lncRNA genes influence the risk of CRC development; polymorphisms in lncRNA HOTTIP, rs145204276 and rs55829688 in lncRNA GAS5, rs2839698 in lncRNA H19, rs2632159 in lncRNA PCAT1, rs2147578 in lnc-LAMC2-1:1, and rs664589 in MALAT1 were associated with a significantly increased CRC risk [67], while rs13252298 and rs1456315 in lncRNA PRNCR1 and rs1194338 in MALAT1 had protective effects on CRC [67,74]. This evidence concerns the gene GAS5 and colorectal carcinoma.