The silencing of UNC5B-AS1, highly expressed in CRC tissues, repressed cancer growth and metastasis, most likely by increasing miR-622 expression and suppression of the AMP-activated protein kinase (AMPK) and the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathways [72]. Here, AKT1 is linked to colorectal carcinoma.