Recently, a functional analysis of transcripts interacting with the PIWIL1–piRNA complex in the CRC COLO 205 cell line suggested that this complex may be directly involved in the activity regulation of key components of signal transduction cascades that are frequently dysregulated in CRC progression, including tumor suppressors and genes involved in the control of cell proliferation and differentiation, such as IGF1R, JUN, and ERBB3 [64]. This evidence concerns the gene PIWIL1 and colorectal carcinoma.