There were no important differences between features representing TNM staging (maximal diameter, multifocality, angioinvasion lymph node metastasis at diagnosis) and BRAF V600E status except for capsule invasion or excision which, for BRAF V600E (+),was almost twice as often than for BRAF V600E (–) and multifocality was more than twice as often as BRAF V600E (–);however, the difference did not reach the level of statistical significance (p-value = 0.08) (Table 1). The gene discussed is BRAF; the disease is metastatic malignant neoplasm in the lymph nodes.