Furthermore, in the study by Liu et al. [41], the –216T allele frequency was found to be significantly higher in NSCLC patients with EGFR tyrosine kinase domain mutations, suggesting that rs712829 SNP may contribute to the development of these mutations, in particular activating deletions in exon 19, and thus leading to a more invasive phenotype. This evidence concerns the gene EGFR and non-small cell lung carcinoma.