ORAI1 and neoplasm: Although STIM/ORAI1-mediated augmented SOCE has been reported to promote tumor growth and metastasis in many cancer types, STIM1 drives growth arrest in human rhabdomyosarcoma and rhabdoid tumor cell lines [64], ORAI1 facilitates apoptosis of PCa cells and the knockdown of ORAI1 leads to drug resistance [65].