Moreover, BRCA1-associated protein-1 (BAP1) is another protein with tumor suppressive properties that has been demonstrated to bind, deubiquitylate and stabilize the activity of the IP3R3 channel in the ER, modulating Ca2+ release into the cytosol and then into mitochondria and thus promoting apoptosis (Table 1 and Figure 2) [98]. This evidence concerns the gene BAP1 and neoplasm.