To prove the role of Neu1 in atherosclerosis, the progression of atherosclerosis was compared in two species of knockout mice, namely Neu3(-/-) Apoe(-/-) and Neu4(-/-) Apoe(-/-) and CathAS190A-Neo Apoe(-/-) mice, which were deficient in Neu1 by 90%. This evidence concerns the gene NEU3 and atherosclerosis.