Moreover, the arteries of CathAS190A-Neo Apoe(-/-) mice were less susceptible to infiltration by macrophages compared to their Neu3(-/-) Apoe(-/-) and Neu4(-/-) Apoe(-/-) counterparts suggesting that two different mechanisms should be responsible for the initiation of the inflammatory response and triggering atherosclerosis [57,117]. This evidence concerns the gene NEU3 and atherosclerosis.