Conversely, miR-139-transfected MDA-MB-231 cells co-treated with an inhibitor against miR-139 (anti-miR-139) regained cell migration and invasion properties (Figure 4E). Collectively, these data indicated that miR-139 down-modulates CXCR4 to show decreased re-differentiation property of stemness, leading to inhibition of tumor metastasis and aggressiveness. Here, CXCR4 is linked to neoplasm.