As CXCR4-induced Akt phosphorylation upregulates VEGF expression in tumor metastasis by enhancing mesenchymal proteins [34], we explored the regulatory action of miR-139 on CXCR4/p-Akt axis with respect to stemness and invasiveness properties of breast cancer cell linking VEGF-mediated EMT. This evidence concerns the gene AKT1 and breast carcinoma.