AKT1 and neoplasm: CSCs phenotypically resemble normal progenitor cells and dysregulation of stemness-related signaling pathways, such as Wnt/β-catenin [6], Hedgehog [7], Notch [8], and PI3K/p-Akt [9], are often due to acquired genetic mutations and/or epigenetic changes in the tumor cells that in turn lead to metastasis and chemoresistance.