Because hormone receptor status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are routinely evaluated for predicting prognosis and determining treatment for breast carcinoma [37], upon stratification of patients according to status of ER, PR or HER2, we performed an association analysis to assess low miR-139 expression level and clinicopathological feature of tumors. The gene discussed is ESR1; the disease is breast carcinoma.