SE- and RF-positive African Americans with RA had a higher risk of rheumatoid nodules development in the presence of the AA and AG genotypes of the IL4R polymorphism rs1801275 (OR = 8.45 [CI: 1.57–45.44], p = 0.01 and OR = 3.57 [CI: 1.18–10.76], p = 0.02, respectively) [36]. Here, IL4R is linked to rheumatoid arthritis.