The highest risk of RA among alleles of the HLA-DRB1 was associated with the allele *01 OR = 4.7 [CI: 3.3–6.8], p = 0.0004 and *04 OR= 3.1 [CI: 2.3–4.26], p = 0.00001. Here, HLA-DRB1 is linked to rheumatoid arthritis.