HNF4A and diabetes mellitus: While no information about this atypical form of diabetes was collected in our cohorts, MODY-related genes have been reported to be epigenetically dysregulated in CRCs (of no particular onset/subtype) [55] and hypermethylated with ageing in people at high risk for metabolic syndromes [56], warranting further investigation as a specific risk factor for EOCRC.