The inhibition of Nrf2 expression can be achieved by inhibiting the RPS6, PTEN/PI3K/Akt/Nrf2, PI3K/AKT/mTOR/RPS6, Nrf2/HO-1, and HER2-AKT/ERK1/2 pathways in GC. The gene discussed is PTEN; the disease is gastric cancer.