CXCL12 and neoplasm: Once they are activated, their presence in the TME is associated with poor clinical outcomes [45,50] due to the secretion of several molecules, such as stromal cell-derived factor 1 (SDF-1), which stimulates tumor angiogenesis [51] (through VEGFB, VEGFC, and PDGFC) and cancer cell colonization and metastasis [52].