It has been reported that pluripotency transcription factors are major Xist repressors in embryonic stem cells [109]; our transcriptomic screen revealed Sox-2 among the activated genes in invasive sarcoma cell lines and, possibly, a similar role of a stemness factor could also be ascribed to FOXD1, at least in the context of induced pluripotent stem cells [110]. The gene discussed is XIST; the disease is sarcoma.