PSPH and sarcoma: On the other hand, the downregulation of Nupr1, Psph, and Tgfb genes was observed in their transcriptome; these genes are part of a specific 10 gene signature of defect mitochondria that has been recently reported in hepatocellular carcinoma [69], which could be interpreted as a reflexion of greater mitochondrial fitness exhibited by invasive sarcoma cell lines.