Despite the controversy regarding the correlation between the expression of AR and ER-β in TNBC, it is important to remember that ER-β is co-expressed with AR and may play a suppressive role in a subset of TNBC such as LAR tumors or apocrine carcinomas, suggesting the need for their combined consideration in the treatment of these tumors. Here, ESR2 is linked to apocrine adenocarcinoma.