KPNA2 and cancer: For example, among the top eight high-significance genes (q-value < 0.005), dysregulation of KPNA2 (Karyopherin α2/Importin α) (q = 0.0009) has long been known to cause mitotic defects, and KPNA2 is reported as overexpressed in various cancers with poor prognosis [24].