A previously unidentified function of KLHL7 (Kelch Like Family Member 7) and KLHL11, components of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, in lung adenocarcinoma genomic instability was also suggested (q = 0.0003, 0.04, respectively). This evidence concerns the gene CUL3 and lung adenocarcinoma.