Indeed, 21 was able to decrease its activity in H295R adrenocortical carcinoma cells (86% aromatase inhibition at 1 μM of 21), which was in good agreement with the docking simulations performed for the complex with a human placental aromatase cytochrome P450 (CYP19A1) model. This evidence concerns the gene CYP19A1 and adrenal cortex carcinoma.