SLC2A1 and cancer: Interestingly, while in the case of [Ru(dip)2(PIP)]2+, internalization in HeLa cancer cells was accomplished by passive diffusion, the uptake of 37 was primarily mediated by the glucose-transporter, with about 20% of it via GLUT and 80% mediated by the sodium-dependent glucose cotransporters (SGLT).