Complex 25 (IC50 to EGFR = 66 nM) showed high cytotoxicity against the A549 non-small-cell lung cancer cell line (IC50 = 15 μM), as well as a tendency to bind preferably to the cell membrane (where EGFR is located) with a portion entering the cell to exert a dual-effect on both enzyme inhibition and DNA binding [87]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.