EGFR and cancer: Many different types of cancer (e.g., lung, colorectal, pancreatic, breast, ovarian, cervical, bladder, neuroendocrine, glioma head, and neck) are associated with abnormalities in the EGFR axis, either by receptor overexpression, disfunction due to mutations, and/or increased autocrine and paracrine production of its growth factors [82,83].