BAK1 and chondrosarcoma: Bak protein was upregulated when exposing the three chondrosarcoma cell lines to miR-491-5p, especially under hypoxia, whereas miR-342-5p tended to decrease Bak expression (from 1.3-fold to 3-fold increase with miR-491-5p and approximately 1.2-fold decrease with miR-342-5p, Figure 8A and Figure S8C).