Previous work on CXCR2 function has shown that it was a pro-angiogenic receptor [16], but it has now been demonstrated, using Cxcr2 knock out (KO) animals, that CXCR2 is also involved in chronic obstructive pulmonary disease [17], wound healing [18], resistance to infections [19], myelin repair [20], metabolism [21] or reproduction under microbiota influence [22]. Here, CXCR2 is linked to chronic obstructive pulmonary disease.