However, one CHD4 cancer-associated mutation located in the Brace-I helix (H1196Y) leads to a gain in remodeling efficiency [258], a result remarkably consistent with that of a similarly located mutation (K938A) introduced in BRG1/Sth1, a SWI/SNF-subfamily remodeler ATPase [14], strongly suggesting a conserved regulatory function for this region across remodelers from different subfamilies. Here, SMARCA4 is linked to cancer.