Mutations in subunits of SWI/SNF-subfamily remodelers are present in >20% of human cancers and are observed at high frequencies in malignant rhabdoid tumors (MRTs) (>95%), ovarian clear cell carcinoma (75%), clear cell renal carcinoma (57%), hepatocellular carcinoma (40%), gastric cancer (36%), melanoma (34%), and pancreatic cancer (26%) [269,270]. The gene discussed is SMARCA1; the disease is melanoma.