CHD5, a paralog of CHD4 that is preferentially expressed in neural tissue and testis, and forms a NuRD-type remodeler [260], is a tumor suppressor involved in the regulation of genes related to neuroblastoma [261] and gliomas [262]; and the interaction of the PHD finger of CHD5 with an unmodified histone H3 tail is essential to restrain tumorous growth of neuroblastoma cells in vivo [263]. The gene discussed is CHD5; the disease is central nervous system cancer.