SMARCB1 and synovial sarcoma: Thus, alongside structural relevance of BAF47 discussed above, the lack of interaction (due to the lack of BAF47 in the context of MRTs) or the hijacking of the interaction with the distal nucleosomal acidic patch (due to the SS18–SSX fusion in the context of synovial sarcoma) can dramatically alter the regulation or the targeting of BAF, respectively.