However, 2% of the MRTs and specific tumors, such as small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), and SMARCA4-deficient thoracic sarcomas (SMARCA4-DTS), present dual deficiencies of BRG1 and BRM via a genetic loss of BRG1 combined with the silencing of BRM [289,290]. The gene discussed is SMARCA2; the disease is ovarian small cell carcinoma.