FGFR3 and achondroplasia: First, Le Merrer et al., Velinov et al. and Francomano et al. determined that the achondroplasia gene was located on 4p16.3, and then, two research groups, those of Shiang et al. and Rousseau, identified mutations in the FGFR3 gene, which are responsible for the majority of achondroplasia cases [12,13].