Based on this rationale, a phase II single-arm study has been planned to investigate efficacy and safety of the combination of niraparib and dostarlimab, a PD-1 inhibitor, in patients with HRD-positive and PD-L1 ≥ 1% advanced non-small-cell lung cancer (NSCLC) and/or MPM [46]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.