All these VOCs, which seem to have independently emerged at different latitudes from convergent selection pressure, tend to share some important mutations, such as L452R, E484K, N501Y, and D614G, which either increase their binding affinity to host receptors (especially to angiotensin-converting enzyme 2; ACE2), or may variably alter their immunogenicity, such that they are less efficiently counteracted by humoral and cellular immune responses that are developed after natural infection with another SARS-CoV-2 strain or after administration of vaccines based on the prototype Wuhan strain [37]. This evidence concerns the gene ACE2 and infection.