In addition, despite the fact that no study has directly investigated the effect of AdipoRon in colorectal cancer (CRC), Malih and Najafi proposed a hypothetical model in which Acrp30 and AdipoRon had a similar behavior in suppressing CRC cell growth, hinting at the employment of this synthetic compound in obesity-related CRC chemoprevention [56]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.