Indeed, although an increase in apoptosis-related proteins has been observed in reaction to AdipoRon administration in PDAC, myeloma and ovarian cancer, programmed cell death does not appear to be the only signaling engaged in AdipoRon-mediated toxicity and, moreover, contrasting evidence also exists regarding the apoptosis involvement, especially in PDAC [52,53,54]. This evidence concerns the gene FAM215A and ovarian cancer.