Practical neuroprotective approaches for managing AD include the discovery of small molecules to block Aβ interactions with its extracellular and intracellular targets [31], to minimize stress kinase signaling cascades [32], to prevent caspase activation [33] and pro-apoptotic protein expression [34], to inhibit excessive tau protein phosphorylation [35], to counteract cholinergic function loss [36], to promote the trophic state and neuron plasticity [37], to hinder reactive oxygen species accumulation [38], to suppress neuroinflammation [39] and to block excitotoxicity [40]. This evidence concerns the gene MAPT and Alzheimer disease.