Although the exact biological cause of AD in most people is still not fully understood, the hallmarks of this disease are believed to be the abnormal deposition of insoluble β-amyloid peptide (Aβ) and the accumulation of neurofibrillary tangles (NFTs) of phosphorylated tau protein in neuronal cytoplasm, which results in atrophy and neuron death [8]. Here, MAPT is linked to Alzheimer disease.