ADCY8 and cancer: In TNBC cells of the MSL subtype, the expression of AC8 and Orai1α is altered to shift the AC8-Orai1α stoichiometry in favor of the former, thus reducing the number of non-AC8-bound Orai1α subunits susceptible to inactivation and, as a result, enhancing SOCE and supporting a variety of cancer hallmarks.