Therefore, based on the involvement of the α-synuclein-mediated microglia activation in PD pathogenesis [58,59,60], and considering the influence of Rhes upon the survival of nigrostriatal dopaminergic neurons [15], in a recent study by Costa and colleagues, the potential role of this protein on the inflammatory response was initially investigated during the physiological brain aging, in both male and female Rhes KO mice [61]. This evidence concerns the gene RASD2 and Parkinson disease.