Accordingly, studies of differential interference contrast microscopy, carried out in the striatal STHdhQ7/Q7 cells, demonstrated that, out of 70% of GFP-Rhes-positive cells showing filopodia-like protrusions, 30% of them exhibited TNT-like structures, thus highlighting a novel ability for Rhes to modulate striatal HD vulnerability [40]. The gene discussed is RASD2; the disease is Huntington disease.