The vitamin D receptors (nuclear receptor—VDRs) are present in several tissues other than the intestine and bones, such as the brain, breast, prostate, lymphocytes, etc. Indeed, recent research showed that higher levels of vitamin D might protect against various pathologies: diabetes mellitus, osteoporosis, osteoarthritis, hypertension, cardiovascular diseases, metabolic syndrome, depression, various autoimmune diseases, neoplasms of the breast, prostate, and colon, etc. [3,4]. This evidence concerns the gene VDR and Hypertension.