For instance, the upregulated blood-based expression of osteopontin (OPN), S-100β, growth differentiation factor-15 (GDF-15), melanoma inhibitory activity (MIA) and B cell-activating factor (BAFF) were confirmed to have associations with the metastases of UM [7,8,9,10,11,12]. The gene discussed is SPP1; the disease is melanoma.