To dissect the role of CUX1 in the tumorigenesis and progression of PDAC, we used the KrasLSL-G12D/+; Ptf1aCre/+ (KC) mouse model, which expresses mutant KRAS in a pancreas-specific manner and faithfully recapitulates the formation of preinvasive pancreatic intraepithelial neoplasia (PanIN) lesions [2]. This evidence concerns the gene CUX1 and keratoconus.