To test the hypothesis that p110 was synergizing with KRAS to promote pancreatic tumor formation, we generated stable p110 CUX1-expressing cell lines using murine mPanIN cells derived from KC mice, human Panc-1 cells and primary human duct-derived hTERT-HPNE cells as an in vitro model for preneoplastic PanINs. Here, KRAS is linked to keratoconus.