The ratio between HDL triglycerides and cholesterol (TG/HDL-C ratio) can be viewed as an index of insulin resistance based on comparisons of the ratio to measures of insulin resistance [66,67], and there is evidence for the association of high TG and low HDL-C with resistance to insulin-stimulated glucose uptake by peripheral tissues independently of body habitus and physical fitness, and that insulin resistance has an effect on plasma insulin, TG, and HDL concentrations [68]. This evidence concerns the gene INS and Insulin resistance.