The network relationship of compound 19 against liver fibrosis was established for the first time with the help of network pharmacology, and it was verified that compound 19 was able to modulate the PI3K/Akt signal and then induce subG1 arrest and activate mitochondrial-mediated apoptosis of t-HSC/Cl-6 cells for preventing liver fibrosis. This evidence concerns the gene PIK3CA and Hepatic fibrosis.