INS and type 2 diabetes mellitus: The NAHNES III study (2007–2012) analyzed 1380 patients with T2DM and revealed that 17% of the patients with CKD were receiving treatment with insulin (16.2%, 27.5%, 24.9%, 22.9% and 38% in stage 1, 2, 3, 4 and 5 of CKD, respectively), and 64% of them were obese (body mass index [BMI] >30 kg/m2) [4].