These guidelines tend to be gradual, depending on the deterioration of metabolic control, and indicate how to start insulin therapies, how to increase the dose of insulin, or when to add rapid insulin BBs, but there are no suggestions on how to decrease or withdraw insulin once the therapy is started (when no up-to-date evidence was available on the benefits and safety in DKD with SGLT2i and GLP1-RA). This evidence concerns the gene INS and diabetic kidney disease.