TERT and neoplasm: In the univariable analysis, age over 55, variant-type PTC, tumor size over 1 cm, the presence of extrathyroidal extension (either microscopic or gross), surgical margin involvement, angioinvasion, T3, T4 stage, Nb stage, overall disease Stages II and III, and a higher MACIS risk score were significantly associated with TERT promoter mutation.