KMT2B and hepatocellular carcinoma: However, recent next-generation sequencing (NGS) analysis of HBV-related HCC revealed a few integration hotspots in close proximity of the oncogenes of telomerase reverse transcriptase (TERT) in 25%, mixed-lineage leukemia 4 (MLL4/KMT2B) in 15%, and cyclin E1 (CCNE1) in 5% of HCC cases, respectively [19].