At the 10-year cumulative incidence of BCR, MTS, CSM and OM, the rates in men with undetectable vs. persistent PSA were 11.3% vs. 32.9% (p = 0.03), 0.6% vs. 0.8% (p = 0.4), 1.0% vs. 4.8% (p = 0.2) and 14.1% vs. 26.6% (p = 0.07), respectively (Figure 3). The gene discussed is KLK3; the disease is ocular melanoma.