Differently to other study groups, men with detected PSA persistence had a significantly increased risk of BCR (HR: 5.1, p < 0.0001), risk of MTS (HR: 2.6, p = 0.015), CSM (HR: 6.2, p = 0.007) and OM (HR: 2.7, p = 0.005) in the multivariate analysis (Table 3). The gene discussed is KLK3; the disease is ocular melanoma.