However, of particular interest, γH2AX immunoreactivity was higher in the APA tumor area than in the adjacent zona glomerulosa, which could be related to the nature of neoplasms and consistent with the frequent genetic alteration detected in APA rather than in non-neoplastic adrenal glands [24,25,39], but further investigations are required for clarification, such as the exact cellular correlation between an induction of CYP11B2 and suppression of cell senescence. Here, CYP11B2 is linked to neoplasm.