The ROS scavenger NAC can revert the accompanied changes caused by combined UVC/sinularin treatment in oral cancer cells, including antiproliferation (MTS and ATP assays), G2/M arrest, apoptosis enhancement (annexin V, pan-caspase, Cas 3/7, and apoptosis signal), oxidative stress appearance (ROS, MitoSOX, and MitoMP), and DNA strand damage (γH2AX and 8-OHdG). This evidence concerns the gene ANXA5 and lip and oral cavity carcinoma.