PDCD1 and Miyoshi myopathy: Although the evaluation of checkpoint inhibitors in combination with IMiD agents in MM has been halted because of an unfavorable benefit/risk profile of the PD-1 inhibitor pembrolizumab plus either lenalidomide-dexamethasone or pomalidomide-dexamethasone [19,20], several ongoing clinical studies are evaluating checkpoint inhibitors in combination with other drugs, such as monoclonal antibodies [21].