Studies have revealed other biomarkers such as neuron-specific enolase, S100B, ubiquitin carboxy-terminal hydrolase-L1, total Tau and cytokines (e.g., IL-1β, IL-6, IL-10, IL-13), tumor necrosis factor alpha, and brain-derived neurotrophic factors are helpful for diagnosing HIE and predicting neurodevelopmental outcomes [22,23,24,25] Unfortunately, tests for most biomarkers are not widely available, and studies evaluating candidate brain injury biomarkers have revealed that no single biomarker is currently in use. This evidence concerns the gene IL6 and perinatal asphyxia.