Venkatesh et al. have demonstrated that the synaptic neuronal protein neuroligin-3 (NLGN3) has a powerful mitogenic activity and soluble NLGN3 was sufficient and necessary to promote high grade glioma cell proliferation in vivo via the PI3K/PTEN/AKT/mTOR signaling pathway [83]. The gene discussed is NLGN3; the disease is central nervous system cancer.