CD28 and myeloid sarcoma: The cytokine production by anti-CD3/anti-CD28-stimulated PBMCs (IL-6, TNF-α, IFN-γ, IL-17, IL-22, and GM-CSF), as well as CD4+ and CD8+ T cells (IL-17 and IFN-γ), was higher in MS patients with fatigue [22].